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Discover dynamic biomarkers beyond the genome.

Our large-scale multi-omics analyses give you an unprecedented view into the factors that modulate health, disease, and drug response across individuals and over time.

One sample, multiple measures, greatly expanded phenotypic insights.

Sapient is a purpose-built biomarker discovery organization providing bespoke multi-omics services for metabolomics, lipidomics, and proteomics data generation and analysis.

Discovery metabolomics and lipidomics at unmatched speed and scale.

Sapient’s next-generation, high throughput mass spectrometry systems capture diverse metabolite and lipid chemistries in a single run.

>15K small molecule biomarkers measured per biosample
High throughput capacity to handle 5K+ samples per day
In-house library with thousands of commercial standards to identify known molecules
Mapping of biologically relevant unknown molecules for novel discovery

Focused small molecule biomarker discovery analyses with rapid time-to-insight.

Sapient’s suite of panels enable targeted exploration of small molecules in specific chemical classes and commonly associated with health and disease.

Ready-to-order panels with customization available
Analyzed using high throughput mass spectrometry for results in <60 days
High-sensitivity measures to detect subtle changes in biomarker levels for known metabolites and/or lipids of interest

High throughput, nontargeted proteomics to meet your study needs for coverage and throughput.

Sapient’s mass spectrometry-based discovery proteomics method extends multi-omics insights with deep coverage of the blood and tissue proteome.

Analytical specificity for high-confidence protein and post-translational modification (PTM) annotation via direct peptide sequencing
Depth and breadth to measure thousands of proteins and PTMs across diverse biological pathways – 4K+ in plasma and 10K+ in cells and tissue
High throughput approach with scalability to process thousands of samples

High-precision quantitative measures for targeted protein panels.

Sapient leverages its mass spectrometry systems for absolute quantitation of key proteins, including difficult-to-measure proteforms of interest.

Direct protein measure with capture of peptide-level information for high analytical specificity
Multiple matrices supported, including cellular, preclinical, and clinical samples
Scalable multiplexing while maintaining high specificity and reproducibility

Through our integrated multi-omics services, we generate greater biological insight from every sample to help you better understand disease and accelerate drug development.

Amplify actionable insight with our integrative multi-omics data analysis.

We offer expert data analysis services to help you map the genetic and phenotypic associations of your identified biomarkers.

BIOCOMPUTATIONAL SERVICES

Gain a comprehensive view of underlying disease biology and drug effects.

Our team uses advanced statistical and ML tools to amalgamate multi-omics, preclinical, and clinical data with human health metadata.

BIOMARKER CROSS-VALIDATION

Understand how your biomarker behaves across large, diverse populations.

Using Sapient’s proprietary Human Biology Database, comprised of data from 100K+ biosamples with paired genetic, phenotypic, and clinical information.

Your multi-omics discovery partner.

Sapient was founded on a core set of discovery values that we bring to every client collaboration, and that we believe are critical to accelerate drug development success.

Rapid time-to-insight.

We know our data drives your
decision-making and have capacity to ensure fast turnaround of results.

Transparent science.

We believe it essential that you have full access to and ownership of your data and findings.

Innovative methods.

We utilize novel technologies and deep expertise to assay thousands of dynamic, non-genetic biomarkers.

Efficient translation.

Our pipeline spans biomarker discovery, validation, and translation, including a CLIA-certified, CAP-accredited lab.

Let’s Talk

Explore the science.

Application Note

Deep Discovery Proteomics in ADC Development: Profiling Cell Surface TAAs

Article

Subtyping, Predicting, and Treating Chronic Kidney Disease: Finding New Paths with Nontargeted Biomarker Discovery

Webinar

Advancing Clinical Biomarkers through Mass Spectrometry-based Discovery Proteomics

Article

How Multi-omics Studies are Unveiling New Insights into Complex Diseases

Article

Dynamic biomarkers to optimize bioprocessing: scale up cell line productivity

Article

Discovery through data transparency: at the heart of scientific collaboration

Join us at the 12th Alzheimer’s and Parkinson’s Drug Development Summit

April 11, 2024

Ready to discover more?

Connect with our scientists to discuss your project or the biological questions you want to answer. We’re here to help you apply our unique multi-omics services at any phase of development.

BOOK A MEETING

10421 Wateridge Circle, Suite 100
San Diego, CA 92121

discover@sapient.bio
858.290.7010